Thionyl Chloride → 4-(2-Piperidin-1-yl-ethoxy)benzyl chloride

HRID 277679Notes

Reaction equation

HRID 277679 reaction equation
O[CH2:2][C:3]1[CH:17]=[CH:16][C:6]([O:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:5][CH:4]=1.NO.S(Cl)([Cl:22])=O>C1COCC1>[Cl:22][CH2:2][C:3]1[CH:17]=[CH:16][C:6]([O:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 69905497amino alcohol 1-[2-(4-Hydroxymethyl-phenoxy)-ethyl]piperidine

Product 1

HCID 98607864-(2-Piperidin-1-yl-ethoxy)benzyl chloride

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This material is prepared from the amino alcohol 1-[2-(4-Hydroxymethyl-phenoxy)-ethyl]piperidine by treatment with thionyl chloride in THF at 0° C. Resulting solid is used without further purification.

Workup

  1. customResulting solid
  2. customis used without further purification

Sources & evidence

ORD record
ord-cfd90462e41f402cb3877ca34c5d879c
Source dataset
uspto-grants-2002_03
Patent number
US06358943B1

Reaction notes

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