反应详情

50 ml of pyridine was added to 2.5 g of 8-hydroxy-5-(α-isopropylaminobutyryl)carbostyril, and 5 ml of isobutyryl chloride was added dropwise to the mixture while cooling with ice-water and stirring followed by stirring for 2 hours. After addition of about 500 ml of diethyl ether, the precipitate formed was washed with diethyl ether and stirred in a small amount of cold water. The precipitate was separated by filtration, washed successively with a small amount of water, acetone and diethyl ether to obtain a crystalline product which was then recrystallized from acetone to obtain 2.1 g of 8-isobutyryloxy-5-(α-Isopropylaminobutyryl)carbostyril hydrochloride having a melting point of 231°-233° C. (with decomposition).

1. additionwas added dropwise to the mixture
2. stirringby stirring for 2 hours
3. customthe precipitate formed
4. washwas washed with diethyl ether
5. stirringstirred in a small amount of cold water
6. customThe precipitate was separated by filtration
7. washwashed successively with a small amount of water, acetone and diethyl ether
8. customto obtain a crystalline product which
9. customwas then recrystallized from acetone