反应详情

1-(2-Methoxyphenyl)-4-[3-(cyclohexanecarbonyl)-3-(phenyl)butyl]piperazine (prepared directly above) was dissolved in warm methanol (50 mL) followed by addition of maleic acid (26.8 g) and MTBE (200 mL). This mixture was concentrated to a paste and then redissolved by addition of methanol (approximately 15 mL) and MTBE (200 mL). The mixture was seeded and an additional amount of MTBE (300 mL) was added once crystallization was initiated. The mixture was suction filtered, and the solid rinsed with MTBE and vacuum dried for 5 hours at 40° C. to provide the title compound (122 g).

1. concentrationThis mixture was concentrated to a paste
2. dissolutionredissolved by addition of methanol (approximately 15 mL) and MTBE (200 mL)
3. additionan additional amount of MTBE (300 mL) was added once
4. customcrystallization
5. filtrationfiltered
6. washthe solid rinsed with MTBE and vacuum
7. customdried for 5 hours at 40° C.