反应详情

25 ml of pyridine was added to 1 g of 5-(1-hydroxy-2-isopropylaminobutyl)-8-hydroxy-3,4-dihydrocarbostyril hydrochloride, and 3 ml of isobutyryl chloride was added dropwise to the mixture while cooling with ice-water and stirring followed by stirring for 3 hours. After addition of about 200 ml of diethyl ether, acetone was added to the precipitate formed to obtain a crystalline product. The product thus obtained was recrystallized from acetone to obtain 0.8 g of 5-(1-hydroxy-2-isopropylaminobutyl)-8-isobutyryloxy-3,4-dihydrocarbostyril hydrochloride having a melting point of 239°-240° C. (with coloration and decomposition).

1. additionwas added dropwise to the mixture
2. stirringby stirring for 3 hours
3. additionwas added to the precipitate
4. customformed
5. customto obtain a crystalline product
6. customThe product thus obtained
7. customwas recrystallized from acetone