Aluminium lithium hydride → HCID 22626824, compound

HRID 277912Notes

Reaction equation

HRID 277912 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].[CH:7]1([CH:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[CH:16]=2)[C:13]#[N:14])[CH2:11][CH2:10][CH2:9][CH2:8]1>C(OCC)C>[CH:7]1([CH:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[CH:16]=2)[CH2:13][NH2:14])[CH2:11][CH2:10][CH2:9][CH2:8]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 22626828HCID 22626828, compound

Product 1

HCID 22626824HCID 22626824, compoundYield 85.8%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

By working in a way similar to that described in example 29 but using LiAlH4 (1.01 g, 26.57 mmoles) in anhydrous ethyl ether (20 ml) and cyclopentyl-(3-methoxy-phenyl)-acetonitrile (5.72 g, 26.57 mmoles), obtained as described in example 32, 5 g of the title compound were obtained (yield: 85.8%).

Workup

  1. customobtained

Sources & evidence

ORD record
ord-bb4b8b2e402a477eace9d7262a732068
Source dataset
uspto-grants-2002_03
Patent number
US06358973B1

Reaction notes

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