HuagongsheHuagongshe Chemistry Print Report · For research reference only
Fluorobenzene → 2-Chloro-5-(4-fluorobenzoyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Fluorobenzene | HCID 10008 | — |
| Reactant | 6-Chloronicotinoyl Chloride | HCID 2782165 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Chloro-5-(4-fluorobenzoyl)pyridine | HCID 22626676 | — |
Reaction Steps
The fluorobenzene (150 ml, 1.60 mmol) and 6-chloronicotinoyl chloride (17.7 g, 100 mmol) were converted to product in a manner substantially analogous to Preparation 1 to yield 15.2 g. (66.1%). EA, MS(FD), NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06358971B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-a66b77c5358044c3925eef8fdd2c6fe6 |
| Source note | uspto-grants-2002_03 |