Fluorobenzene → 2-Chloro-5-(4-fluorobenzoyl)pyridine

HRID 277920Notes

Reaction equation

HRID 277920 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:8][C:9]1[CH:17]=[CH:16][C:12]([C:13](Cl)=[O:14])=[CH:11][N:10]=1>CC(=O)OCC>[Cl:8][C:9]1[CH:17]=[CH:16][C:12]([C:13](=[O:14])[C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)=[CH:11][N:10]=1

Participants

4

Reactant 2

HCID 10008FluorobenzeneHCID 27821656-Chloronicotinoyl Chloride

Product 1

HCID 226266762-Chloro-5-(4-fluorobenzoyl)pyridine

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The fluorobenzene (150 ml, 1.60 mmol) and 6-chloronicotinoyl chloride (17.7 g, 100 mmol) were converted to product in a manner substantially analogous to Preparation 1 to yield 15.2 g. (66.1%). EA, MS(FD), NMR.

Workup

  1. customto yield 15.2 g

Sources & evidence

ORD record
ord-a66b77c5358044c3925eef8fdd2c6fe6
Source dataset
uspto-grants-2002_03
Patent number
US06358971B1

Reaction notes

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