反应详情

A stirred solution of 4′-bromo-2,2,2-trifluoroacetophenone (0.392 g, 2.00 mmol) and CH3NO2 (0.488 g, 8.0 mmol) in dry toluene (70 mL) containing N,N-diethylenediamine (30 mmol) is heated at reflux with a Dean and Stark trap until complete removal of H2O. The cooled solution is washed with 5% aqueous HCl, dried over MgSO4, filtered, evaporated in vacuo and the resulting residue when purified by chromatography gives the title compound.

1. temperatureis heated
2. washThe cooled solution is washed with 5% aqueous HCl
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. customevaporated in vacuo
6. customthe resulting residue when purified by chromatography