反应详情

温度

0 °C

Sodium metal (8.68 g, 378 mmol) was added to methanol (350 mL) pre-cooled to 0° C. After the sodium completely dissolved, 2-chloro-5-nitro-6-methylpyridine (40.78 g, 236 mmol) was slowly added as a solid. The reaction mixture was heated at reflux temperature overnight, then poured into ice-water. The product was filtered and dried in vacuo overnight to give 29.39 grams of the title compound. (73%).

1. temperatureThe reaction mixture was heated
2. temperatureat reflux temperature overnight
3. filtrationThe product was filtered
4. customdried in vacuo overnight