反应详情

0.33 g of benzyl [1-(5-amino-[1,3,4]oxadiazol-2-yl)-3-phenylpropyl]carbamate were dissolved in 50 ml of dry methanol at RT, treated under argon with hydrogenation catalyst (10% palladium on carbon), and hydrogenated at RT for 3 h. The reaction mixture was filtered off through Celite, the filtrate was concentrated under reduced pressure, and the residue was dried under high vacuum. 5-(1-Amino-3-phenylpropyl)-[1,3,4]oxadiazol-2-ylamine was obtained, which was employed in the next stage without further purification.

1. filtrationThe reaction mixture was filtered off through Celite
2. concentrationthe filtrate was concentrated under reduced pressure
3. customthe residue was dried under high vacuum