Benzyl [1-(5-amino-[1,3,4]oxadiazol-2-yl)-3-phenylpropyl]carbamate → 5-(1-Amino-3-phenylpropyl)-[1,3,4]oxadiazol-2-ylamine

Participants

Reaction Steps

0.33 g of benzyl [1-(5-amino-[1,3,4]oxadiazol-2-yl)-3-phenylpropyl]carbamate were dissolved in 50 ml of dry methanol at RT, treated under argon with hydrogenation catalyst (10% palladium on carbon), and hydrogenated at RT for 3 h. The reaction mixture was filtered off through Celite, the filtrate was concentrated under reduced pressure, and the residue was dried under high vacuum. 5-(1-Amino-3-phenylpropyl)-[1,3,4]oxadiazol-2-ylamine was obtained, which was employed in the next stage without further purification.

Provenance & Evidence