Isobutyryl chloride → HCID 22627179, compound

HRID 278071Notes

Reaction equation

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]([O:12][CH3:13])=[O:11])[CH:8]=2)[CH:3]=[CH:2]1.[C:14](Cl)(=[O:18])[CH:15]([CH3:17])[CH3:16]>>[C:14]([C:3]1[C:4]2[C:9](=[CH:8][C:7]([C:10]([O:12][CH3:13])=[O:11])=[CH:6][CH:5]=2)[NH:1][CH:2]=1)(=[O:18])[CH:15]([CH3:17])[CH3:16]

Participants

Reactant 2

HCID 62325Isobutyryl chloride

HCID 639844Methyl indole-6-carboxylate

Product 1

HCID 22627179HCID 22627179, compound

Procedure

Methyl 3-isobutyrylindole-6-carboxylate (618 mg) was prepared from methyl indole-6-carboxylate (500 mg) and isobutyryl chloride (0.84 ml) in a similar manner to that of Preparation 1 (5).

Sources & evidence

ORD record: ord-d2184fb3c74c4a02a14c5f1581dc46c6
Source dataset: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06358992B1

Reaction notes

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