反应详情

To a solution of methyl 3-nitro-4-(2-oxopentyl)benzoate (114 mg) in a mixture of tetrahydrofuran (1.5 ml), ethanol (1.5 ml) and water (2.1 ml) was added sodium hydrosulfite (3.0 g), and the mixture was stirred under reflux for 30 minutes. The resulting mixture was evaporated in vacuo, and the residue was diluted with ethyl acetate. The organic phase was washed with water and brine, dried over sodium sulfate and evaporated in vacuo. The residue was purified by thin layer chromatography with a mixture of hexane and ethyl acetate (2:1) to give methyl 2-propylindole-6-carboxylate (54.6 mg).

1. temperatureunder reflux for 30 minutes
2. customThe resulting mixture was evaporated in vacuo
3. additionthe residue was diluted with ethyl acetate
4. washThe organic phase was washed with water and brine
5. dry with materialdried over sodium sulfate
6. customevaporated in vacuo
7. customThe residue was purified by thin layer chromatography with a mixture of hexane and ethyl acetate (2:1)