HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Aminomethyl-3'-hydroxybiphenyl hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-{N-(tert-butyloxycarbonyl)aminomethyl}-3'-hydroxybiphenyl | HCID 22627110 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Aminomethyl-3'-hydroxybiphenyl hydrochloride | HCID 22627090 | — |
Reaction Steps
A solution of 2-{N-(tert-butyloxycarbonyl)aminomethyl}-3′-hydroxybiphenyl from Step G (0.732 g, 2.45 mmol) in EtOAc (30 mL) at 0° C. was saturated with HCl gas. The mixture was aged at 0° C. for 5 min, then concentrated to dryness in vacuo to provide the titled compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06358985B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-923bc92bd2a44988abd75885b88e1df7 |
| Source note | uspto-grants-2002_03 |