Hydrochloric Acid → 2-Aminomethyl-3'-hydroxybiphenyl hydrochloride

HRID 278170Notes

Reaction equation

HRID 278170 reaction equation
C(OC([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([OH:22])[CH:17]=1)=O)(C)(C)C.[ClH:23]>CCOC(C)=O>[ClH:23].[NH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([OH:22])[CH:17]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 226271102-{N-(tert-butyloxycarbonyl)aminomethyl}-3'-hydroxybiphenyl

Product 1

HCID 226270902-Aminomethyl-3'-hydroxybiphenyl hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 2-{N-(tert-butyloxycarbonyl)aminomethyl}-3′-hydroxybiphenyl from Step G (0.732 g, 2.45 mmol) in EtOAc (30 mL) at 0° C. was saturated with HCl gas. The mixture was aged at 0° C. for 5 min, then concentrated to dryness in vacuo to provide the titled compound as a white solid.

Workup

  1. customat 0° C.
  2. concentrationconcentrated to dryness in vacuo

Sources & evidence

ORD record
ord-923bc92bd2a44988abd75885b88e1df7
Source dataset
uspto-grants-2002_03
Patent number
US06358985B1

Reaction notes

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