Hydrochloric Acid → HCID 178499561, compound

Participants

Reaction Steps

A solution of 4-imidazoleacetic acid hydrochloride (4.0 g, 24.6 mmol) in MeOH (100 mL) was saturated with HCl gas at ambient temperature. Trimethyl orthoformate (10 mL) was added, and the mixture was stirred at ambient temperature overnight then concentrated to dryness in vacuo. The solid was redissolved in MeOH (100 mL) and the above procedure repeated to yield the titled compound as a white solid.

Provenance & Evidence