Hydrochloric Acid → HCID 178499561, compound

HRID 278172Notes

Reaction equation

HRID 278172 reaction equation
[ClH:1].[NH:2]1[CH:6]=[C:5]([CH2:7][C:8]([OH:10])=[O:9])[N:4]=[CH:3]1.Cl.[CH:12](OC)(OC)OC>CO>[ClH:1].[NH:2]1[CH:6]=[C:5]([CH2:7][C:8]([O:10][CH3:12])=[O:9])[N:4]=[CH:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 9005Trimethyl orthoformateHCID 178479752HCID 178479752, compound

Product 1

HCID 178499561HCID 178499561, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4-imidazoleacetic acid hydrochloride (4.0 g, 24.6 mmol) in MeOH (100 mL) was saturated with HCl gas at ambient temperature. Trimethyl orthoformate (10 mL) was added, and the mixture was stirred at ambient temperature overnight then concentrated to dryness in vacuo. The solid was redissolved in MeOH (100 mL) and the above procedure repeated to yield the titled compound as a white solid.

Workup

  1. concentrationthen concentrated to dryness in vacuo
  2. dissolutionThe solid was redissolved in MeOH (100 mL)

Sources & evidence

ORD record
ord-e9dfdc3b7e484bc59400cb0359f40ea9
Source dataset
uspto-grants-2002_03
Patent number
US06358985B1

Reaction notes

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