Thionyl Chloride → 2-Chloromethyl-3'-benzyloxybiphenyl

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Reaction Steps

To a solution of (3′-benzyloxybiphenyl-2-yl)methanol from Example 4, Step E (247 mg, 0.851 mmol) in dry CH2Cl2 (5 mL) was added thionyl chloride (1.01 g, 8.51 mmol). The reaction mixture was stirred at ambient temperature for 2 hours, then concentrated to dryness in vacuo. The residue was concentrated twice from cyclohexane in vacuo to yield the titled compound.

Provenance & Evidence