反应详情

A solution of 4-phenylbutyl bromide from the Step A (24.7 g) and triphenylphosphine (19.00 g) in toluene (100 mL) was heated at 120-130° C. for 3 days. The reaction was cooled to rt and the solid precipitate was collected by filtration, washed with toluene and air dried. The solid was dissolved in a 2:1 mixture of water and acetonitrile and gave the title compound (30.6 g) as a white solid after lyopholization.

1. filtrationthe solid precipitate was collected by filtration
2. washwashed with toluene and air
3. customdried
4. dissolutionThe solid was dissolved in a 2:1 mixture of water and acetonitrile