Trifluoroacetic acid → 4-(Imidazo[1,2-a]pyridin-3-yl)piperidine di-TFA salt

HRID 278241Notes

Reaction equation

HRID 278241 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]3=[N:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[C:23]([OH:29])([C:25]([F:28])([F:27])[F:26])=[O:24]>>[OH:29][C:23]([C:25]([F:28])([F:27])[F:26])=[O:24].[OH:29][C:23]([C:25]([F:28])([F:27])[F:26])=[O:24].[N:16]1[CH:15]=[C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[N:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=12

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21912736Tert-butyl 4-(imidazo[1,2-a]pyridin-3-yl)piperidine-1-carboxylate

Product 1

HCID 1317231484-(Imidazo[1,2-a]pyridin-3-yl)piperidine di-TFA salt

Procedure

To 100 mg of 1-(t-butoxycarbonyl)4-(imidazo[1,2-a]pyridin-3-yl)piperidine from Step A was added 2 mL TFA. The reaction was stirred at rt for 1 h. The mixture was concentrated under reduced pressure to afford 180 mg of a viscous oil.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-bac13f724ca44af5a268498e9ea4b620
Source dataset
uspto-grants-2002_03
Patent number
US06358979B1

Reaction notes

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