HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 278253Generated: October 26, 2026
Ammonium formate → 4-(2-Ethyl-4,5,6,7-tetrahydro-2h-indazol-3-yl)piperidine
https://huagongshe.com/reaction/278253
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | 4-(2-Ethyl-4,5,6,7-tetrahydro-(2H)-indazol-3-yl)-1-benzylpiperidine | HCID 21912783 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(2-Ethyl-4,5,6,7-tetrahydro-2h-indazol-3-yl)piperidine | HCID 21912746 | 97.5% |
Reaction Steps
A mixture of 0.273 g 4-(2-ethyl4,5,6,7-tetrahydro-(2H)-indazol-3-yl) -1-benzylpiperidine from Step B above, 0.789 g ammonium formate, and 35 mg 20% Pd(OH)2 in 6 mL methanol was heated at 65° C. for 1 h. Basic aqueous work-up with ether extraction provided 0.192 g title compound as a colorless solid (97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06358979B1 |
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| Source dataset | uspto-grants-2002_03 |
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| ORD ID | ord-1d2092ca66954fe39f42cc4c721bf36b |
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| Source note | uspto-grants-2002_03 |
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