反应详情

温度

65 °C

A mixture of 0.273 g 4-(2-ethyl4,5,6,7-tetrahydro-(2H)-indazol-3-yl) -1-benzylpiperidine from Step B above, 0.789 g ammonium formate, and 35 mg 20% Pd(OH)2 in 6 mL methanol was heated at 65° C. for 1 h. Basic aqueous work-up with ether extraction provided 0.192 g title compound as a colorless solid (97%).

1. extractionBasic aqueous work-up with ether extraction