反应详情

温度

90 °C

The compound 4-pyridyloxyundecan-1-ol was prepared as follows: To a solution of 4-hydroxy-pyridine (5.71 g, 60 mmol) in DMF (150 cm3) was added cesium carbonate (19.56 g, 60 mmol). The mixture was heated to 90° C. for 5 mins then 11-bromoundecanol (12.56 g, 50 mmol) was added and the mixture heated to reflux temperature (125° C.) for 15 hours. After cooling, the contents of the flask were poured into rapidly stirring distilled water (800 cm3). A pale yellow precipitate formed which was filtered and dried (in air). Recrystallization from hexane gave white crystals of 4-pyridyloxyundecan-1-ol (2.9 g, 22%).

1. customThe compound 4-pyridyloxyundecan-1-ol was prepared
2. temperaturethe mixture heated
3. temperatureto reflux temperature (125° C.) for 15 hours
4. temperatureAfter cooling
5. additionthe contents of the flask were poured
6. distillationdistilled water (800 cm3)
7. customA pale yellow precipitate formed which
8. filtrationwas filtered
9. customdried (in air)
10. customRecrystallization from hexane