Ammonia → HCID 178422859, compound

HRID 278408Notes

Reaction equation

HRID 278408 reaction equation
[NH2:1][OH:2].[NH3:3].[C:4]([O:10]C)(=O)[CH2:5][C:6]([CH3:8])=O.[OH2:12]>>[OH:12][C:4]1[O:2][N:1]=[C:6]([CH3:8])[C:5]=1[C:4]1[O:10][N:3]=[C:6]([CH3:8])[CH:5]=1

Participants

5

Reactant 4

HCID 222AmmoniaHCID 787HydroxylamineHCID 962WaterHCID 7757Methyl acetoacetate

Product 1

HCID 178422859HCID 178422859, compound

Procedure

208 g of a 50% aqueous hydroxylamine solution and 91 ml of 28% aqueous ammonia were added to 350 ml of water, into which 348 g of methyl acetoacetate was dropped over 50 minutes at temperature below 15° C. After the completion of the dropping, the reaction solution returned to room temperature and stood undisturbed for 6 days to give 900 ml of an aqueous solution of crude ammonium salt of 5 -hydroxy-3-methyl-4-(3-methylisooxazol-5-yl)isoxazole.

Workup

  1. additionwas dropped over 50 minutes at temperature below 15° C
  2. customreturned to room temperature

Sources & evidence

ORD record
ord-f58240facde64f2690787357bd7d7a56
Source dataset
uspto-grants-2002_03
Patent number
US06359143B1

Reaction notes

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