HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (RS)-1-(6-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-4-(4-methyl-benzyl)-piperidin-4-ol Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (RS)-1-(6-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-4-(4-methyl-benzyl)-piperidin-4-ol | HCID 9842071 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (RS)-1-(6-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-4-(4-methyl-benzyl)-piperidin-4-ol Hydrochloride | HCID 22628391 | 97% |
Reaction Steps
To (RS)-1-(6-hydroxy-1,2,3 ,4-tetrahydro-naphthalen-2-ylmethyl)-4-(4-methyl-benzyl)-piperidin-4-ol (500 mg, 1.36 mmol) in EtOH (4 ml) at 4° C., was added ethanolic HCl (1.1 eq.). Evaporation of the EtOH afforded the title compound as a white foam (530 mg, 1.32 mmol, 97%), MS m/e=366.2 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06359138B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-b07dcc1a44f64d2c83540a0681a2e5e9 |
| Source note | uspto-grants-2002_03 |