反应详情

To (RS)-1-(6-hydroxy-1,2,3 ,4-tetrahydro-naphthalen-2-ylmethyl)-4-(4-methyl-benzyl)-piperidin-4-ol (500 mg, 1.36 mmol) in EtOH (4 ml) at 4° C., was added ethanolic HCl (1.1 eq.). Evaporation of the EtOH afforded the title compound as a white foam (530 mg, 1.32 mmol, 97%), MS m/e=366.2 (M+H+).

1. customEvaporation of the EtOH