(RS)-5-Benzyloxy-2-bromomethyl-2,3-dihydro-benzofuran → 1-(5-Benzyloxy-2,3-dihydro-benzofuran-2-ylmethyl)-4-(4-methoxy-benzyl)-piperidin-4-ol

HRID 278421Notes

Reaction equation

HRID 278421 reaction equation
[CH3:1][O:2][C:3]1[CH:16]=[CH:15][C:6]([CH2:7][C:8]2([OH:14])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:5][CH:4]=1.[CH2:17]([O:24][C:25]1[CH:26]=[CH:27][C:28]2[O:32][CH:31]([CH2:33]Br)[CH2:30][C:29]=2[CH:35]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:17]([O:24][C:25]1[CH:26]=[CH:27][C:28]2[O:32][CH:31]([CH2:33][N:11]3[CH2:10][CH2:9][C:8]([CH2:7][C:6]4[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:16][CH:15]=4)([OH:14])[CH2:13][CH2:12]3)[CH2:30][C:29]=2[CH:35]=1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 22628347(RS)-5-Benzyloxy-2-bromomethyl-2,3-dihydro-benzofuranHCID 226283494-[(4-Methoxyphenyl)methyl]piperidin-4-ol

Product 1

HCID 226283951-(5-Benzyloxy-2,3-dihydro-benzofuran-2-ylmethyl)-4-(4-methoxy-benzyl)-piperidin-4-ol

Procedure

The title compound MS: m/e=460.2 (M+H+) was prepared from 4-(4-methoxy-benzyl)-piperidin-4-ol and 5-benzyloxy-2-(RS)-bromomethyl-2,3-dihydro-benzofuran.

Sources & evidence

ORD record
ord-42db4a37e5764a1f93209c98f3a623a7
Source dataset
uspto-grants-2002_03
Patent number
US06359138B1

Reaction notes

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