反应详情

This solution of bromoacetate is added dropwise to the prepared solution of benzyloxyethanolate anion, and the mixture is heated at reflux for 19 h. The reaction is stopped with 5% KHSO4. 250 ml ethyl acetate is added and the organic phase is extracted three times with the aid of 5% NaOH. The pH of the alkaline phase is reduced to 1 with 10% HCl and extraction is performed twice with EtOAc. The organic phase is washed three times with sodium chloride solution, dried on Na2SO4, and evaporated to obtain 6.4 g (93%) 7-phenyl-3,6-dioxaheptanoic acid in the form of a colourless liquid.

1. temperaturethe mixture is heated
2. temperatureat reflux for 19 h
3. extractionthe organic phase is extracted three times with the aid of 5% NaOH
4. extractionThe pH of the alkaline phase is reduced to 1 with 10% HCl and extraction
5. washThe organic phase is washed three times with sodium chloride solution
6. customdried on Na2SO4
7. customevaporated