Hydrochloric Acid → 1-(Naphthalene-2-sulfonyl)piperazine hydrochloride

HRID 278545Notes

Reaction equation

HRID 278545 reaction equation
C([N:3]1[CH2:8][CH2:7][N:6]([S:9]([C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]=2)(=[O:11])=[O:10])[CH2:5][CH2:4]1)=O.[ClH:22]>C(O)C>[ClH:22].[CH:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:20]=[CH:21][C:12]=1[S:9]([N:6]1[CH2:7][CH2:8][NH:3][CH2:4][CH2:5]1)(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 176421771-Formyl-4-(2-naphthalenesulfonyl)piperazine

Product 1

HCID 227218151-(Naphthalene-2-sulfonyl)piperazine hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 1-formyl-4-(2-naphthalenesulfonyl)piperazine was added ethanol (30 ml) and 1 N hydrochloric acid (100 ml), and the solution was stirred for 5 hours under reflux. The reaction solution was concentrated, and the residue was washed with ethyl acetate and dried under reduced pressure to give 1-(2-naphthalenesulfonyl)piperazine hydrochloride (43.3 g).

Workup

  1. temperatureunder reflux
  2. concentrationThe reaction solution was concentrated
  3. washthe residue was washed with ethyl acetate
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-d4cabe490f9c497a9e0a24af883c7a0a
Source dataset
uspto-grants-2002_03
Patent number
US06359134B1

Reaction notes

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