Hydrochloric Acid → 1-(6-Chloronaphth-2-ylsulphonyl)piperazine hydrochloride

Participants

Reaction Steps

To 1-(tert-butoxycarbonyl)-4-(6-chloronaphthalene-2-sulfonyl)piperazine (2.0 g) were added methanol (10 ml)and 4 N hydrochloric acid in ethyl acetate solution (20 ml), and the solution was stirred at room temperature 30 minutes. The reaction solution was concentrated, and the residue was treated with acetone to give amorphous powder which was dried under reduced pressure to give the title compound (1.66 g).

Provenance & Evidence