Hydrochloric Acid → 1-(6-Chloronaphth-2-ylsulphonyl)piperazine hydrochloride

HRID 278547Notes

Reaction equation

HRID 278547 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[C:22]([Cl:27])[CH:23]=3)[CH:18]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.CO.Cl>C(OCC)(=O)C>[ClH:27].[Cl:27][C:22]1[CH:23]=[C:24]2[C:19](=[CH:20][CH:21]=1)[CH:18]=[C:17]([S:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)(=[O:15])=[O:16])[CH:26]=[CH:25]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 187613901-Boc-4-(6-chloronaphthalen-2-ylsulfonyl)piperazine

Product 1

HCID 227097661-(6-Chloronaphth-2-ylsulphonyl)piperazine hydrochlorideYield 196.4%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 1-(tert-butoxycarbonyl)-4-(6-chloronaphthalene-2-sulfonyl)piperazine (2.0 g) were added methanol (10 ml)and 4 N hydrochloric acid in ethyl acetate solution (20 ml), and the solution was stirred at room temperature 30 minutes. The reaction solution was concentrated, and the residue was treated with acetone to give amorphous powder which was dried under reduced pressure to give the title compound (1.66 g).

Workup

  1. concentrationThe reaction solution was concentrated
  2. additionthe residue was treated with acetone
  3. customto give amorphous powder which
  4. customwas dried under reduced pressure

Sources & evidence

ORD record
ord-8ad2f9a62cb94ec6ad4e525958f1d571
Source dataset
uspto-grants-2002_03
Patent number
US06359134B1

Reaction notes

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