反应详情

To a solution of methyl 5-bromo-2-thiophenecarboxylate (884 mg), 4-pyridyl boric acid (500 mg), tetrakistriphenylphosphine palladium(0) (250 mg) in dimethoxyethane (15 ml) was added 2 M sodium carbonate solution (4 ml) and the solution was heated for 15 hours under reflux. The reaction solution was diluted with ethyl acetate and the organic layer was separated, washed with water and extracted with 1 N hydrochloric acid. The extract was made alkaline with sodium hydroxide solution and extracted with ethyl acetate. The extract was dried and concentrated to give pale yellow solid of methyl 5-(4-pyridyl)-2-thiophenecarboxylate (428 mg).

1. temperaturethe solution was heated for 15 hours
2. temperatureunder reflux
3. customthe organic layer was separated
4. washwashed with water
5. extractionextracted with 1 N hydrochloric acid
6. extractionextracted with ethyl acetate
7. customThe extract was dried
8. concentrationconcentrated