反应详情

To a solution of the obtained ethyl 4-(1,2,4-triazol-4-yl)benzoate (365 mg) in ethanol (4 ml)-THF (4 ml) was added 1 N sodium hydroxide solution (4 ml), and the solution was stirred at room temperature for 2 hours. The reaction solution was concentrated and the residue was dissolved in water, to which was added 1 N hydrochloric acid (4 ml). The precipitate was filtered, washed with water and dried to give the title compound, 4-(1H-imidazol-4-yl)benzoic acid (275 mg).

1. concentrationThe reaction solution was concentrated
2. dissolutionthe residue was dissolved in water, to which
3. additionwas added 1 N hydrochloric acid (4 ml)
4. filtrationThe precipitate was filtered
5. washwashed with water
6. customdried