Hydrochloric Acid → 216959-72-7

HRID 278583Notes

Reaction equation

HRID 278583 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([S:10]([N:13]3[CH2:18][CH2:17][N:16](C=O)[CH2:15][CH2:14]3)(=[O:12])=[O:11])=[CH:7][C:6]=2[CH:21]=1.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([S:10]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)(=[O:11])=[O:12])=[CH:7][C:6]=2[CH:21]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22627946HCID 22627946, compound

Product 1

HCID 22710538216959-72-7Yield 150.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1-(5-chlorobenzofuran-2-sulfonyl)-4-formylpiperazine (405 mg) in ethanol (15 ml) was added concentrated hydrochloric acid (1 ml), and the mixture was heated for 30 minutes under reflux. The solid obtained by concentration was washed with ethyl acetate and dried to give a colorless solid of the title compound (312 mg).

Workup

  1. temperaturethe mixture was heated for 30 minutes
  2. temperatureunder reflux
  3. customThe solid obtained by concentration
  4. washwas washed with ethyl acetate
  5. customdried

Sources & evidence

ORD record
ord-c9b91728a658438892cde2f6b3602d34
Source dataset
uspto-grants-2002_03
Patent number
US06359134B1

Reaction notes

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