HCID 57194982, compound → HCID 86757884, compound

HRID 278632Notes

Reaction equation

HRID 278632 reaction equation
C([O:5][C:6](=[O:46])[C@H:7]([CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[NH:8][CH2:9][CH:10]1[C:22]2[C:17](=[C:18]3[CH:30]=[CH:29][CH:28]=[CH:27][C:19]3=[C:20]3[CH:26]=[CH:25][CH:24]=[CH:23][C:21]3=2)[C:16]2[C:11]1=[C:12]1[CH:38]=[CH:37][CH:36]=[CH:35][C:13]1=[C:14]1[CH:34]=[CH:33][CH:32]=[CH:31][C:15]1=2)(C)(C)C>FC(F)(F)C(O)=O.O.C(OCC)C>[CH:23]1[C:21]2[C:20](=[C:19]3[CH:27]=[CH:28][CH:29]=[CH:30][C:18]3=[C:17]3[C:22]=2[CH:10]([CH2:9][NH:8][C@H:7]([C:6]([OH:46])=[O:5])[CH2:39][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[C:11]2[C:16]3=[C:15]3[CH:31]=[CH:32][CH:33]=[CH:34][C:14]3=[C:13]3[CH:35]=[CH:36][CH:37]=[CH:38][C:12]3=2)[CH:26]=[CH:25][CH:24]=1

Participants

5

Reactant 1

HCID 57194982HCID 57194982, compound

Product 1

HCID 86757884HCID 86757884, compound

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 3283Diethyl EtherSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of Nα-17-tetrabenzo(a,c,g,i)fluorenylmethyl-L-phenylalanine tert-butyl ester (421.1 mg, 0.702 mmol) in trifluoroacetic acid (3.6 ml) and water (0.2 ml) was sonicated for 3.5 h at room temperature. The solvent was removed in vacuo to give a brown residue. Trituration in diethylether gave the compound (53) as a yellow solid which was chilled overnight, filtered, washed with ether, and finally dried (352.7 mg, 92%);

Workup

  1. customThe solvent was removed in vacuo
  2. customto give a brown residue

Sources & evidence

ORD record
ord-794986d2ae89458d9b0c565ef573e32c
Source dataset
uspto-grants-2002_03
Patent number
US06359113B1

Reaction notes

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