Potassium Carbonate → 1-Ethynyl-4-(1-isopropoxycyclopropyl)-benzene

HRID 278710Notes

Reaction equation

HRID 278710 reaction equation
[CH:1]([O:4][C:5]1([C:8]2[CH:13]=[CH:12][C:11]([C:14]#[C:15][Si](C)(C)C)=[CH:10][CH:9]=2)[CH2:7][CH2:6]1)([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[C:14]([C:11]1[CH:12]=[CH:13][C:8]([C:5]2([O:4][CH:1]([CH3:3])[CH3:2])[CH2:6][CH2:7]2)=[CH:9][CH:10]=1)#[CH:15]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22568899[4-(1-Isopropoxycyclopropyl)phenylethynyl]-trimethylsilane2×

Product 1

HCID 225688581-Ethynyl-4-(1-isopropoxycyclopropyl)-benzene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [4-(1-isopropoxycyclopropyl)-phenylethynyl]-trimethylsilane (Intermediate 65, 260.0 mg, 0.96 mmol) in methanol (10 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (220 mg, 100%) was used directly in the next reaction.

Sources & evidence

ORD record
ord-1f879ce9d67d4fc39aa7f68787216409
Source dataset
uspto-grants-2002_03
Patent number
US06359135B1

Reaction notes

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