反应详情

温度

50 °C

To a solution of 3-isopropyl-phenol (5.00 g, 36.2 mmols) in 50 mL of acetone was added K2CO3(7.50 g, 54.3 mmols) and iodomethane (10.3 g, 72.5 mmols). The resulting solution was heated to 50° C. and stirred for 18 hours, cooled to room temperature, and concentrated under reduced pressure. The residual oil was dissolved in Et2O and washed with H2O, saturated aqueous NaHCO3, and saturated aqueous NaCl before being dried (MgSO4) and concentrated under reduced pressure. The crude methyl ether was used without further purification.

1. temperaturecooled to room temperature
2. concentrationconcentrated under reduced pressure
3. dissolutionThe residual oil was dissolved in Et2O
4. washwashed with H2O, saturated aqueous NaHCO3, and saturated aqueous NaCl
5. dry with materialbefore being dried (MgSO4)
6. concentrationconcentrated under reduced pressure
7. customThe crude methyl ether was used without further purification