Hydrochloric Acid → HCID 135856758, compound

HRID 278868Notes

Reaction equation

HRID 278868 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][OH:21])[CH2:15][CH2:14]2)(=[O:12])=[O:11])=[CH:6][C:5]=1[C:22]1[NH:27][C:26](=[O:28])[C:25]2=[C:29]([CH3:35])[N:30]=[C:31]([CH2:32][CH2:33][CH3:34])[N:24]2[N:23]=1)[CH3:2].[ClH:36]>CCOCC>[ClH:36].[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][OH:21])[CH2:15][CH2:14]2)(=[O:12])=[O:11])=[CH:6][C:5]=1[C:22]1[NH:27][C:26](=[O:28])[C:25]2=[C:29]([CH3:35])[N:30]=[C:31]([CH2:32][CH2:33][CH3:34])[N:24]2[N:23]=1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 1354877322-[2-ethoxy-5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonylphenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Product 1

HCID 135856758HCID 135856758, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

200 mg (0.39 mmol) of 2-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-piperazine-1-sulphonyl]-phenyl}-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one are suspended in ether, admixed with 2 ml of a 1M solution of HCl in ether and stirred at room temperature for 20 minutes. The solvent is removed, giving 209 mg (100%) of 2-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-piperazine-1-sulphonyl]-phenyl}-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one hydrochloride.

Workup

  1. customThe solvent is removed

Sources & evidence

ORD record
ord-0733684fd55d4ec6a1eceec1f4e51c30
Source dataset
uspto-grants-2002_03
Patent number
US06362178B1

Reaction notes

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