Water → 2,3,4,5,11,15b-hexahydro-1H-dibenz[3,4:6,7]azepino[1,2-a](1,4)diazepine

HRID 27888Notes

Reaction equation

O=[C:2]1[CH2:8][CH2:7][N:6]2[C:9]3[CH:21]=[CH:20][CH:19]=[CH:18][C:10]=3[CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[CH:5]2[CH2:4][NH:3]1.O>C1COCC1>[CH2:4]1[NH:3][CH2:2][CH2:8][CH2:7][N:6]2[C:9]3[CH:21]=[CH:20][CH:19]=[CH:18][C:10]=3[CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[CH:5]12

Participants

Conditions

Temperature: 0 °C

Procedure

A solution of 7.5 g 2,3,4,5,11,15b-hexahydro-3-oxo-1H-dibenz[3,4:6,7]azepino[1,2-a](1,4)diazepine in 200 ml THF is added to a vigorously stirred suspension of 5 g LiALH4 in 400 ml dry THF. The mixture is boiled under reflux for 3 hours, after which it is cooled to about 0° C. 20 ml water is then added slowly to the mixture and the inorganic precipitate which forms is removed by filtration. The filtrate is evaporated to dryness, leaving a crystalline residue. Yield 5.3 g.

Workup

temperatureunder reflux for 3 hours
customthe inorganic precipitate which forms is removed by filtration
customThe filtrate is evaporated to dryness
customleaving a crystalline residue

Sources & evidence

ORD record: ord-04490b33a97c443a8cb6ee4929ac67ce
Source dataset: uspto-grants-1980_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04224321

Reaction notes

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