反应详情

温度

0 °C

A solution of 7.5 g 2,3,4,5,11,15b-hexahydro-3-oxo-1H-dibenz[3,4:6,7]azepino[1,2-a](1,4)diazepine in 200 ml THF is added to a vigorously stirred suspension of 5 g LiALH4 in 400 ml dry THF. The mixture is boiled under reflux for 3 hours, after which it is cooled to about 0° C. 20 ml water is then added slowly to the mixture and the inorganic precipitate which forms is removed by filtration. The filtrate is evaporated to dryness, leaving a crystalline residue. Yield 5.3 g.

1. temperatureunder reflux for 3 hours
2. customthe inorganic precipitate which forms is removed by filtration
3. customThe filtrate is evaporated to dryness
4. customleaving a crystalline residue