反应详情

A mixture of 3.54 g (0.01 moles) of 3-chloro-6-(3,5-dimethyl-4-phthalimido-1-pyrazolyl)-pyridazine, 40 ml of ethanol and 1.08 g (0.01 moles) of 98% hydrazine hydrate is heated to reflux for 3 hours and the mixture is poured into 100 ml of water. After cooling the precipitated crystals are filtered, washed with water, triturated with 10 ml of hot ethanol, filtered and dried. Yield: 1.8 g (81%); m.p. 165°-168° C.

1. temperatureis heated
2. temperatureto reflux for 3 hours
3. temperatureAfter cooling the precipitated crystals
4. filtrationare filtered
5. washwashed with water
6. customtriturated with 10 ml of hot ethanol
7. filtrationfiltered
8. customdried