反应详情

A mixture of 34.2 g. of 3-chloro-6-(3,5-dimethyl-1-pyrazolyl)-pyridazine, 100 ml of 72% hydrazine hydrate and 200 ml of dioxane is stirred at 90°-95° C. for 14 hours, then the mixture is poured into 1 liter of water, extracted three times with 150 ml of chloroform each, and the combined organic phases are dried over magnesium sulphate. After evaporation of the solvent, the residue is recrystallized from isopropanol. Yield: 27 g /80%/; m.p.: 142°-143° C.

1. additionA mixture of 34.2 g
2. extractionextracted three times with 150 ml of chloroform each, and the combined organic phases
3. dry with materialare dried over magnesium sulphate
4. customAfter evaporation of the solvent
5. customthe residue is recrystallized from isopropanol