HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Tert-butyldimethylsilyoxy-5-nitro-benzo[de]isoquinoline-1,3-dione → 5-Amino-2-tert-butyldimethylsilyoxy-benzo[de]isoquinoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Tert-butyldimethylsilyoxy-5-nitro-benzo[de]isoquinoline-1,3-dione | HCID 131722278 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-Amino-2-tert-butyldimethylsilyoxy-benzo[de]isoquinoline-1,3-dione | HCID 131722280 | 86.5% |
Reaction Steps
The hydrogenation of 2-tert-butyldimethylsilyoxy-5-nitro-benzo[de]isoquinoline-1,3-dione (1.0 g, 2.7 mmol, from Example A-1 or A-2) at 40 psi in the presence of 10% Pd/C catalyst (1.0 g) in ethyl acetate (20 mL) afforded 0.8 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06362181B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-bf15403a3e3e4498bc22b7453ef3f626 |
| Source note | uspto-grants-2002_03 |