HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 2-Benzyloxy-5-bromo-6-(4-methylpiperazin-1-yl)-benzo[de]isoquinoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 2-Benzyloxy-5-bromo-6-nitro-benzo[de]isoquinoline-1,3-dione | HCID 22623982 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Benzyloxy-5-bromo-6-(4-methylpiperazin-1-yl)-benzo[de]isoquinoline-1,3-dione | HCID 22623927 | 38.2% |
Reaction Steps
Following the procedure of Example U1, 2-benzyloxy-5-bromo-6-nitro-benzo[de]isoquinoline-1,3-dione (0.50 g, 1.2 mmol, from Example S1-A) and 1-methylpiperazine (0.46 g, 4.7 mmol) in DMF (5 mL) were reacted to give 0.22 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06362181B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-57a58329ffdb406eb9020e6d8c992d4e |
| Source note | uspto-grants-2002_03 |