1-Methylpiperazine → 2-Benzyloxy-5-bromo-6-(4-methylpiperazin-1-yl)-benzo[de]isoquinoline-1,3-dione

HRID 278966Notes

Reaction equation

HRID 278966 reaction equation
[CH2:1]([O:8][N:9]1[C:18](=[O:19])[C:17]2[CH:20]=[C:21]([Br:26])[C:22]([N+:23]([O-])=O)=[C:15]3[C:16]=2[C:11](=[CH:12][CH:13]=[CH:14]3)[C:10]1=[O:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:28][N:29]1[CH2:34][CH2:33]N[CH2:31][CH2:30]1>CN(C=O)C>[CH2:1]([O:8][N:9]1[C:18](=[O:19])[C:17]2[CH:20]=[C:21]([Br:26])[C:22]([N:23]3[CH2:33][CH2:34][N:29]([CH3:28])[CH2:30][CH2:31]3)=[C:15]3[C:16]=2[C:11](=[CH:12][CH:13]=[CH:14]3)[C:10]1=[O:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 226239822-Benzyloxy-5-bromo-6-nitro-benzo[de]isoquinoline-1,3-dione

Product 1

HCID 226239272-Benzyloxy-5-bromo-6-(4-methylpiperazin-1-yl)-benzo[de]isoquinoline-1,3-dioneYield 38.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following the procedure of Example U1, 2-benzyloxy-5-bromo-6-nitro-benzo[de]isoquinoline-1,3-dione (0.50 g, 1.2 mmol, from Example S1-A) and 1-methylpiperazine (0.46 g, 4.7 mmol) in DMF (5 mL) were reacted to give 0.22 g of the title compound.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-57a58329ffdb406eb9020e6d8c992d4e
Source dataset
uspto-grants-2002_03
Patent number
US06362181B1

Reaction notes

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