Acetylacetone → 4-[6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazin-3-yl]morpholine

HRID 27898Notes

Reaction equation

HRID 27898 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[N:8]=[N:9][C:10]([NH:13][NH2:14])=[CH:11][CH:12]=2)[CH2:3][CH2:2]1.[C:15]([CH2:18][C:19](=O)[CH3:20])(=O)[CH3:16]>C(O)C>[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[N:8]=[N:9][C:10]([N:13]3[C:19]([CH3:20])=[CH:18][C:15]([CH3:16])=[N:14]3)=[CH:11][CH:12]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 31261AcetylacetoneHCID 12603548HCID 12603548, compound

Product 1

HCID 30990544-[6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazin-3-yl]morpholine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1.95 g (0.01 moles) of 3-morpholino-6-pyridazinylhydrazine, 1.0 g (0.01 moles) of acetylacetone and 20 ml of ethanol is heated to reflux for 3 hours. After cooling the separated crystals are filtered, washed with ethanol and dried. Yield: 1.65 g (64.5%); m.p. 119°-121° C.

Workup

  1. temperatureis heated
  2. temperatureto reflux for 3 hours
  3. temperatureAfter cooling the separated crystals
  4. filtrationare filtered
  5. washwashed with ethanol
  6. customdried

Sources & evidence

ORD record
ord-510458d0ff42413090bb5cb719ecbed0
Source dataset
uspto-grants-1980_09
Patent number
US04224325

Reaction notes

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