反应详情

The hydrogenation of 2-benzyloxy-5-methyl-benzo[de]isoquinoline-1,3-dione (0.4 g, 1.3 mmol, from Example P) was performed in the presence of 10% Pd/C (0.1 g) in DMA (20 mL). Purification of crude product by column chromatography (silica gel using 10% methanol in dichloromethane) gave 0.1 g of the title compound, mp 251-253° C.;

1. customPurification of crude product by column chromatography (silica gel using 10% methanol in dichloromethane)