Phenylsilane → HCID 22624016, compound

HRID 279023Notes

Reaction equation

HRID 279023 reaction equation
C([O:4][N:5]1[C:14](=[O:15])[C:13]2[CH:16]=[C:17]([CH3:19])[CH:18]=[C:11]3[C:12]=2[C:7](=[CH:8][CH:9]=[C:10]3[N:20]2[CH2:24][CH2:23][CH2:22][CH2:21]2)[C:6]1=[O:25])C=C.C1([SiH3])C=CC=CC=1>C(Cl)Cl.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[OH:4][N:5]1[C:14](=[O:15])[C:13]2[CH:16]=[C:17]([CH3:19])[CH:18]=[C:11]3[C:12]=2[C:7](=[CH:8][CH:9]=[C:10]3[N:20]2[CH2:24][CH2:23][CH2:22][CH2:21]2)[C:6]1=[O:25]

Participants

5

Reactant 2

HCID 12752PhenylsilaneHCID 22623960HCID 22623960, compound

Product 1

HCID 22624016HCID 22624016, compoundYield 65.6%

Reagents, catalysts & solvents 2

HCID 178418397HCID 178418397, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

Following the procedure of Example 59, 2-allyloxy-5-methyl-7-(pyrrolidin-1-yl)-benzo[de]isoquinoline-1,3-dione (0.55 g, 1.8 mmol, from Example J2), phenylsilane (0.29 g, 2.6 mmol), Pd(PPh3)4 (0.81 g, 0.070 mmol) in CH2Cl2 (40 mL) were reacted to give 0.35 g of the title compound, mp 236-237° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-a6ae2e3b839743a29027ea51c2a2ed04
Source dataset
uspto-grants-2002_03
Patent number
US06362181B1

Reaction notes

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