Trifluoroacetic acid → HCID 22623920, compound

HRID 279026Notes

Reaction equation

HRID 279026 reaction equation
C(O)(C(F)(F)F)=O.[C:8]([NH:11][C:12]1[C:13]([N:32]2[CH2:36][CH2:35][CH2:34][CH2:33]2)=[C:14]2[CH:23]=[CH:22][CH:21]=[C:20]3[C:15]2=[C:16]([CH:31]=1)[C:17](=[O:30])[N:18]([O:25]C(C)(C)C)[C:19]3=[O:24])(=[O:10])[CH3:9]>>[C:8]([NH:11][C:12]1[C:13]([N:32]2[CH2:36][CH2:35][CH2:34][CH2:33]2)=[C:14]2[CH:23]=[CH:22][CH:21]=[C:20]3[C:15]2=[C:16]([CH:31]=1)[C:17](=[O:30])[N:18]([OH:25])[C:19]3=[O:24])(=[O:10])[CH3:9]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22623933HCID 22623933, compound

Product 1

HCID 22623920HCID 22623920, compoundYield 0%

Procedure

Following the procedure from Example 62, TFA (1.0 mL) and 5-acetamido-2-tert-butyloxy-6-(pyrrolidin-1-yl)-benzo[de]isoquinoline-1,3-dione (0.2 g, 0.5 mol, from Example Q2) was stirred at room temperature overnight. It was concentrated, and the solid recrystallized from ethanol/ether to give 0.02 g of the title compound, mp 280-284° C.

Workup

  1. concentrationIt was concentrated
  2. customthe solid recrystallized from ethanol/ether

Sources & evidence

ORD record
ord-6a20853e956744ad91d510acc3c7e14f
Source dataset
uspto-grants-2002_03
Patent number
US06362181B1

Reaction notes

Loading…