Hydrochloric Acid → HCID 22624007, compound

HRID 279027Notes

Reaction equation

HRID 279027 reaction equation
C([NH:4][C:5]1[C:6]([N:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)=[C:7]2[CH:16]=[CH:15][CH:14]=[C:13]3[C:8]2=[C:9]([CH:20]=1)[C:10](=[O:19])[N:11]([OH:18])[C:12]3=[O:17])(=O)C.Cl>CCO>[NH2:4][C:5]1[C:6]([N:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)=[C:7]2[CH:16]=[CH:15][CH:14]=[C:13]3[C:8]2=[C:9]([CH:20]=1)[C:10](=[O:19])[N:11]([OH:18])[C:12]3=[O:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22623920HCID 22623920, compound

Product 1

HCID 22624007HCID 22624007, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 5-acetamido-2-hydroxy-6-(pyrrolidin-1-yl)-benzo[de]isoquinoline-1,3-dione (200 mg, 0.59 mmol, from Example 64) was added 40% HCl in EtOH (5.0 mL) at 60° C. overnight, followed by cooling, concentrating, and recrystallization of the residue from ethanol/water solution to give the title compound mp 253-256° C.

Workup

  1. temperatureby cooling
  2. concentrationconcentrating
  3. customrecrystallization of the residue from ethanol/water solution

Sources & evidence

ORD record
ord-9c867ae9ad964fff9b6ca92927e589b7
Source dataset
uspto-grants-2002_03
Patent number
US06362181B1

Reaction notes

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