反应详情

To 5-acetamido-2-hydroxy-6-(pyrrolidin-1-yl)-benzo[de]isoquinoline-1,3-dione (200 mg, 0.59 mmol, from Example 64) was added 40% HCl in EtOH (5.0 mL) at 60° C. overnight, followed by cooling, concentrating, and recrystallization of the residue from ethanol/water solution to give the title compound mp 253-256° C.

1. temperatureby cooling
2. concentrationconcentrating
3. customrecrystallization of the residue from ethanol/water solution