Trifluoroacetic acid → HCID 22623941, compound

HRID 279029Notes

Reaction equation

HRID 279029 reaction equation
C([O:5][N:6]1[C:15](=[O:16])[C:14]2[CH:17]=[C:18]([N+:20]([O-:22])=[O:21])[CH:19]=[C:12]3[C:13]=2[C:8](=[CH:9][CH:10]=[C:11]3[N:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)[C:7]1=[O:28])(C)(C)C.C(O)(C(F)(F)F)=O>O>[OH:5][N:6]1[C:15](=[O:16])[C:14]2[CH:17]=[C:18]([N+:20]([O-:22])=[O:21])[CH:19]=[C:12]3[C:13]=2[C:8](=[CH:9][CH:10]=[C:11]3[N:23]2[CH2:24][CH2:25][CH2:26][CH2:27]2)[C:7]1=[O:28]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22624012HCID 22624012, compound

Product 1

HCID 22623941HCID 22623941, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2-t-butyloxy-5-nitro-7-(pyrrolidin-1-yl)-benzo[de]isoquinoline-1,3-dione (0.09 g, 0.23 mmol, from Example D3-B) and TFA was stirred at room temperature for 4 hours and poured into water. The solid was filtered and washed with acetone to give (0.06 g, 80%) of the title compound, mp 290-291° C.

Workup

  1. filtrationThe solid was filtered
  2. washwashed with acetone

Sources & evidence

ORD record
ord-8328a5ee125a419dbc65c6985377367c
Source dataset
uspto-grants-2002_03
Patent number
US06362181B1

Reaction notes

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